Significantly worse survival for Black patients was also seen in those <65 years of age (P < 0.001), ≥65 years (P = 0.011), with invasive ductal carcinoma (P < 0.001), with ER+/PR+ disease (P = 0.006), undergoing modified radical mastectomy (P = 0.002), receiving lymph node dissection (P < 0.001), undergoing adjuvant radiotherapy (P = 0.003), with nodal metastasis (P < 0.001), with stage II (P = 0.005) and stage III (P = 0.005) disease, and with grade II (P = 0.005) and grade III (P = 0.014) disease when compared to the other races. The gene discussed is ESR1; the disease is invasive ductal breast carcinoma.