CD8A and neoplasm: Interestingly, tumor antigen-specific IFN-γ production was detected in dLNs from untreated iNKT−/− mice (33.08 ± 10.04 pg/mL for AH1-A5 versus 9.65 ± 10.86 pg/mL for pMCMV, p = 0.05) (Figure 3), a finding consistent with the ability of these mice to inhibit lung metastases in a CD8-dependent manner [25].