To determine if blockade of CD1d resulted in improved priming of anti-tumor CD8+ T cells in dLN of WT mice treated with local radiotherapy and anti-CTLA-4 mAb [25], we measured tumor antigen-specific production of IFNγ by dLN cells stimulated with a CD8 T cell epitope derived from the tumor antigen gp70 [31]. The gene discussed is CD8A; the disease is neoplasm.