Blockade of CD1d in WT mice increased not only locoregional DC numbers, but also the priming of tumor-specific CD8 T cells in dLN and the overall tumor response to treatment with radiotherapy and anti-CTLA-4 mAb, suggesting that temporarily “disabling” iNKT cells was sufficient to enhance Th1 type anti-tumor immunity. This evidence concerns the gene CTLA4 and neoplasm.