Changes in cytokine secretion are reported not only with many luminal enteric microbial infections but increased levels of pro-inflammatory cytokines (interleukin (IL)-6, IL-8, and tumour necrosis factor-α (TNF-α)) have been reported in the plasma and peripheral blood mononuclear cells of IBS patients [6]. The gene discussed is CXCL8; the disease is irritable bowel syndrome.