Using the threshold of 1% positively-stained nuclei used in the histological classification of breast cancer, we observed the following: 52.8% of WDLS, 22.5% of DDLS, 3.3% of PLS, and 10.4% of MLS were scored as ER+; 16.5% of WDLS, 10.2% of DDLS, 0% of PLS, and 9% of MLS were scored as PR+; 70% of WDLS, 36.2% of DDLS, 15.6% of PLS, and 19.2% of MLS were scored as AR + . Here, ESR1 is linked to breast cancer.