In this article, we introduce a novel prediction model using a multiple logistic regression model by incorporating widely used tumor pathologic variables of tumor type, grade and mitotic index, tumor receptors (triple-negative, HER2+ versus HER2−, ER− versus ER2+) and pretreatment functional parameters of tHb, oxyHb and deoxyHb. The gene discussed is ERBB2; the disease is neoplasm.