In contrast to previous observations in the EAE model,26 the absence of Ackr2 resulted in a statistically significant increase in the clinical symptoms of arthritis (Figure 1b), and a substantial increase (P<0.05) in the cumulative clinical score of Ackr2-deficient mice (24.2±3.6, mean±s.d). The gene discussed is ACKR2; the disease is arthritic joint disease.