Given the regulatory role of ACKR2 during inflammation and T-cell priming, it is important that studies are now undertaken to further investigate the expression and regulation of ACKR2 in the inflamed tissues and draining LNs of patients with autoimmune disease, and it remains to be seen whether ACKR2-mediated chemokine scavenging can influence disease progression in humans. Here, ACKR2 is linked to autoimmune disease.