We considered whether loss of the anti-inflammatory activity of ACKR2 at this site might have a more pronounced effect on the development of autoimmune disease than it is reported to have in the brain.26 To explore this, we backcrossed Ackr2-deficient C57BL/6J mice onto DBA/1j and monitored development of arthritis in a large cohort of animals after immunization with bovine type II collagen, using WT DBA1/j littermate mice as controls. The gene discussed is ACKR2; the disease is arthritic joint disease.