PIK3CA and squamous cell lung carcinoma: However, the Cancer Genome Atlas Research Network performed a comprehensive genomic analysis of 178 squamous cell lung cancers and reported the following genetic alterations: PIK3CA mutations in 16%, PTEN mutation/deletion in 15%, FGFR1 amplification in 15%, EGFR amplification in 9%, PDGFRA amplification in 9%, DDR2 mutation in 4%, and unknown genetic alterations in 21% [8].