Brightly stained myelinated fibres were present in some of these dermal nerve bundles in both patients with carpal tunnel syndrome (Fig. 3C) and control participants with a comparable percentage of PGP+ dermal bundles containing MBP+ fibres [median (IQR) carpal tunnel syndrome: 1.22 (0.38); controls: 1.31 (0.35), P = 0.38, Fig. 3E]. This evidence concerns the gene MBP and carpal tunnel syndrome.