When using SNVs only, most such genes were known cancer genes, such as U2AF1, IDH1, and DNMT3A in LAML (FLT3 SNVs cluster within five amino acids), AKT1 and KRAS in BRCA, BRAF and KRAS in COADREAD, IDH1 and PARG (poly (ADP-ribose) glycohydrolase) in GBM, and KRAS in UCEC. Here, IDH1 is linked to cancer.