Indeed, it has been shown that MSC from adipose tissue induce an inhibition of CD8+CD28− cells [50], while others, in accordance with our data, have shown that MSC from bone marrow induce an increase of this population thus contributing to the attenuation of refractory dry eye secondary to chronic graft-versus-host-disease [51]. The gene discussed is CD8A; the disease is Keratoconjunctivitis sicca.