We included known missense mutations in six bona fide oncogenes (BRAF, KIT, PIK3CA, KRAS, EGFR, ERRB2), six recently described cancer genes (ESR1, DICER1, MYOD1, IDH1, IDH2, SF3B1) and three bona fide TSGs (TP53, BRCA1, BRCA2) in this study. Here, PIK3CA is linked to cancer.