To this extent, two different groups have recently generated TREM-1 deficient mice [46,47], with Weber and Colleagues demonstrating that TREM-1 genetic deletion ameliorates dextran sulfate sodium (DSS)-induced colitis while it does not appear to affect control of the infection by specific pathogens, such as Leishmania Major, influenza virus and Legionella pneumoniae, displaying however a reduced neutrophil infiltration [46]. The gene discussed is TREM1; the disease is colitis.