PPP2CA and type 2 diabetes mellitus: To see if these epigenetic changes induced by hyperglycemia observed in β cells are readable in a more reachable tissue in human, we analyzed DNA methylation in whole blood cells (WBCs) of diabetic patients, and found that patients with T2D were consistently less methylated than controls at the Pp2ac locus, more notably in a regulatory zone called “CpG island shore” (Irizarry et al. 2009).