In T2D patients, we found a significant albeit limited hypomethylation of the CpG island (CGI; 2.8 ± 0.5 vs. 3.2 ± 0.7 in controls, P =0.01) and of the CGI shore (72.1 ± 3.4 vs. 74.8 ± 2.6 in controls, P =0.005) located in the Pp2ac gene promoter region (Fig. 3, Table 4). This evidence concerns the gene PPP2CA and type 2 diabetes mellitus.