Significant interactions were observed between treatment groups over time for fasting insulin (F6,65 = 2.92; P < 0.05; Fig. 2B) and HOMA (F6,65 = 2.96; P < 0.05; Fig. 2C), with HF‐SED animals having greater fasting insulin (P < 0.05) and HOMA (P < 0.05) than HF‐EX, LF‐SED, and LF‐EX animals at 8 and 12 weeks. Here, INS is linked to hydrops fetalis.