HIF1A and obesity due to melanocortin 4 receptor deficiency: Vascular endothelial growth factor (VEGF) is a downstream target of HIF‐1α whose gene expression within adipose tissue has been shown to increase with obesity (He et al. 2011) and may be necessary for WAT growth (Nishimura et al. 2007), perhaps by promoting angiogenesis and preventing WAT hypoxia and attenuating inflammation.