A recent study where another DUB USP7, originally a nuclear protein present inside the PML (promyelocytic leukemia) bodies is tethered to the cytoplasm by Infected Cell protein 0 (ICP0) oncoprotein of Herpes Simplex Virus where it deubiquitinates and stabilizes TNF receptor associated Factor 6 (TRAF6) and Iκκ-γ [45], also beautifully illustrate this paradigm. The gene discussed is PML; the disease is acute promyelocytic leukemia.