ESR1 and exostosis: The Rotterdam Study (of 1483 individuals), using directmolecular haplotyping to determine the relationship between2 polymorphisms in the ERα gene demonstrated a significantassociation with the presence of osteophytes in Knee OA17.Our data suggests that patients with the A allele presentedwith slightly worse radiographic scores, however nostatistically significant differences were observed betweengroups.