ESR1 and osteoarthritis, knee: It has been reported that oestrogen receptor alpha (ER-α)polymorphisms are associated with knee osteoarthritis (OA).In this study, we assessed whether there was any associationbetween the codon 594 (G>A) polymorphism in ER-α andradiographic features of OA or patient function.Radiographs, WOMAC score and patient reported time ofsymptom onset were assessed in 194 patients presenting fortotal knee replacement at Ramathibodi hospital over a oneyear period.