Interestingly, Nfkbid−/− mice show a high sensitivity to lipopolysaccharide (LPS)-induced endotoxin shock and 4,4-dimethyl-4-silapentane-1-sulfonic acid-induced colitis because Nfkbid−/− DCs and macrophages produce large amounts of IL-6 in response to LPS stimulation [3]. The gene discussed is IL6; the disease is colitis.