In line with TGF-β1's critical role of collagen induction in response to high glucose and hypertension [14], TGF-β1-induced ERK activation and CTGF (connective tissue growth factor) signaling in both proximal tubular epithelial and mesangial cells were all inhibited by fluorofenidone [15], [17]. The gene discussed is CCN2; the disease is hypertensive disorder.