It was also shown that a combination of ATRA and IFN-γ expressed higher levels of HLA class II and HLA-DM molecules in glioblastoma T98G and U87MG cells than IFN-γ alone suggesting that the combination of ATRA with IFN-γ may overcome the defect in class II-mediated immune recognition of glioblastoma. The gene discussed is HLA-DMA; the disease is glioblastoma.