MPO was identified as one of two predictors of cardiotoxicity in breast cancer patients treated with ACs and Herceptin, from a panel of potential biomarkers including CRP, NT-proBNP, growth differentiation factor (GDF)-15, placenta growth factor (PlGF), soluble fms-like tyrosine kinase receptor (sFlt)-1, and galectin (gal)-3 (89). The gene discussed is PGF; the disease is breast carcinoma.