Of the 10 criteria, some are evident, such as “the condition sought should be an important health problem.” And of the 10, the two that deserve additional mention here are “there should be an accepted treatment for patients with recognized disease,” and “there should be an agreed policy on whom to treat as patients.” Both of these questions were addressed by a large randomized study that evaluated the cardioprotective effects of enalapril, an angiotensin-converting-enzyme inhibitor routinely used for congestive heart failure (130). This evidence concerns the gene ACE and congestive heart failure.