CCKBR and familial pancreatic carcinoma: Supporting this conjecture, recent studies by our group indicate that blockade of CCKR signaling with a broad-spectrum CCKAR and CCKBR antagonist significantly reduced fibrosis surrounding mPanIN lesions in 8 month old Pdx1-Cre/ LSL-KrasG12D mice, a transgenic model of pancreatic cancer (unpublished data).