IRSp53, which is phosphorylated upon stimulation with insulin (80, 81), is a key factor in cytoskeleton reorganization that mediates neurite outgrowth (82), being also involved in several neurodegenerative disorders (83), because IRSp53-deficient animals record cognitive deficits in the contextual fear-conditioning paradigm (84). The gene discussed is BAIAP2; the disease is Cognitive impairment.