For example, force generation of cardiomyocytes from tissue samples of affected patients was reduced compared to control for β-MyHC mutations, mutations in the cMyBPC, and for FHC-patients with unidentified mutations (Hoskins et al., 2010; van Dijk et al., 2012; Kraft et al., 2013). The gene discussed is MYBPC3; the disease is hypercholesterolemia, familial, 1.