In vitro motility and ATPase-assays on isolated sarcomeric proteins together with the analysis of mouse models led to the hypothesis that enhanced calcium-sensitivity, increased maximal force generation, and higher ATPase activity are the common features of FHC-related mutations (Robinson et al., 2002, 2007; Debold et al., 2007), resulting in impaired energy metabolism (Spindler et al., 1998; Blair et al., 2001) and altered calcium-handling in cardiomyocytes (Baudenbacher et al., 2008; Guinto et al., 2009). Here, DNAH8 is linked to hypercholesterolemia, familial, 1.