KCNMA1 and idiopathic generalized epilepsy: In addition, a gain-of-function mutation in KCNMA1 has been reported to result in a syndrome of coexistent generalized epilepsy and paroxysmal dyskinesia in humans (Du et al., 2005); Gain-of-function mutations in the β1 subunit were associated with low prevalence of diastolic hypertension (Fernández-Fernández et al., 2004).