Also, there are accumulating evidences that altered ribosomal proteins [10, 11] and nuclear proteins [12–14] such as Twist, upstream binding factor (UBF), Fibrillarin, nucleophosmin (NPM, B23), exportin1 (XPO1) and importin7 (IPO7) are involved in cancer progression [15]. The gene discussed is NPM1; the disease is cancer.