Calu-3, which is another NSCLC cell possessing the hypomethylated CpG islands of TM4SF4 gene (Figure 1D), also overexpressed TM4SF4 (Figure 1A) and showed similar patterns of cell growth and radiation resistance as A549 cells when expression of TM4SF4 was suppressed or overexpressed (Supplementary Figure 1A). The gene discussed is TM4SF4; the disease is non-small cell lung carcinoma.