Genetic abnormalities of the phosphatidylinositil-3- kinase (PI3K)/AKT pathway are common in human cancer, and there is increasing evidence of PI3K/AKT being involved in the development of many types of cancers [6, 7], thus making PI3K/AKT and its downstream pathways promising targets for therapeutic intervention [8, 9]. The gene discussed is PIK3CA; the disease is cancer.