Consistently, Rac1 activity assay demonstrated an association between Rac1 protein level and Rac1 activity in these cells, showing that much higher Rac1 activities were detected in AsPC-1, CD18/HPAF and Capan-1 pancreatic cancer cells compared to HPNE cells (Fig. 2B). The gene discussed is ITGB2; the disease is familial pancreatic carcinoma.