As integrin signaling was previously shown to be involved in cancer stem/progenitor cell maintenance [21, 46, 47] and bone metastasis [22, 48-50], we strongly believe that the disturbance of F-actin via GSK-3β inhibition, thereby leading to reduced integrin-mediated adhesion and signaling, is responsible for the decrease in prostate cancer stemness and bone metastasis. The gene discussed is GSK3B; the disease is Familial prostate cancer.