PTEN and neoplasm: This action of Kindlin-3 is similar to that displayed by PTEN, a known tumor suppressor gene, which has also been shown to antagonize interactions of integrins with the extracellular matrix and integrin-triggered signaling pathways by dephosphorylating focal adhesion kinase (FAK), resulting in inhibition of integrin-mediated cell spreading, migration, and invasion [37].