Kindlin-3 promoter was significantly hypermethylated at the TSS (Fig. 2A) as well as in the first intron (supplementary Figure 2a) in most cancer samples analysed (breast cancer vs normal breast P=0.0006 and 0.02; melanoma vs nevi P=0.0055 and 0.03 respectively). The gene discussed is FERMT3; the disease is cancer.