INS and Hyperglycemia: Taken together with the findings that empagliflozin treatment substantially improved hyperglycemia, the greater body weight and the higher serum insulin levels in empagliflozin-treated db/db mice than in control (untreated) db/db mice can be explained by the significant prevention by empagliflozin of aging-associated decrease in serum insulin levels and of aging-associated loss of body weight gain in db/db mice.