In conclusion, glycemic control with empagliflozin ameliorated cardiac fibrosis and inflammation, coronary arterial remodeling, vascular dysfunction, cognitive decline as well as glomerular injury in obese type 2 diabetic mice, thereby highlighting empagliflozin, a SGLT2 inhibitor, as potentially a promising agent for prevention of diabetic macrovascular disease and cognitive decline as well as nephropathy. This evidence concerns the gene SLC5A2 and Nephropathy.