APOE and endothelial dysfunction: In ApoE−/− mice, an endothelial dysfunction, characterised by reduced ACh‐mediated relaxation, has been reported in plaque‐laden regions of the aorta, for example, in mice on a western‐style diet and in older ApoE−/− mice on a normal diet (Deckert et al. 1999; Yang et al. 1999).