Taking advantage of a model of oral candidiasis in transgenic mice expressing HIV-1 [39], which display an AIDS-like disease [52], we here show that defective IL-17- and IL-22-dependent induction of oral antimicrobial peptide expression in response to C. albicans infection is indeed central to the phenotype of susceptibility to OPC in these HIV-transgenic mice. This evidence concerns the gene IL17A and oral candidiasis.