In previous work, we found that CD4+ T-cells are depleted in the oral mucosa, CLNs and peripheral blood of CD4C/HIVMutA Tg mice, that CD4+ cells harvested from Tg mice 7 days after infection fail to proliferate and to acquire an effector phenotype in response to C. albicans antigen in vitro, and that transfer of CD4+ T-cells from uninfected non-Tg mice into infected Tg mice restores cell proliferation and sharply reduces oral burdens of C. albicans [40]. Here, CD4 is linked to infection.