While hypermethylation-related repression of the HSPA2 gene in primary bladder tumors has been reported (Costa et al. 2010; Reinert et al. 2011), others found the HSPA2 gene to be highly expressed in bladder cancer cell lines and in primary urothelial tumors (Garg et al. 2010b). This evidence concerns the gene HSPA2 and urinary bladder neoplasm.