To define the intrinsic pathways regulating CD8+ T cell tolerance versus immunity, the gene expression profiles of Gag-specific CD8+ T cells (TCRGag) were defined after transfer into normal B6 mice (naive), B6 mice with an immunogenic Gag-positive FBL tumor (immune), or Alb∶Gag mice that express the same Gag antigen under control of the Albumin promoter in healthy hepatocytes (tolerant) [27]. The gene discussed is CD8A; the disease is neoplasm.