Although our study sample size was not negligible, as a cross-sectional study, it would have been more valuable to have had an appropriate follow up to address the association of APS and SLE polyautoimmunity by the inclusion of other measurements such as antibodies isotypes (e.g., B2GPI IgA [90], RF IgG), serologic biomarkers and genetic markers. The gene discussed is APOH; the disease is autoimmune polyendocrinopathy.