Positivity for RF IgG was negatively associated with serosal and hematological involvement, and negatively correlated with aCL IgG titer, suggesting that RF IgG is related with the absence of APS; on the other hand, RF IgM was associated with aCL IgM positivity, implying a possible relation with APS [52]. Here, CD40LG is linked to autoimmune polyendocrinopathy.