Previous reports showed that IFN-γ has protective effects in models of autoimmune disease including in experimental autoimmune encephalomyelitis (EAE) model mice, although EAE is regarded as a T helper (Th)-17 (IL-17) and Th-1 (IFN-γ)-dependent autoimmune disease [22]–[25]. The gene discussed is IFNG; the disease is experimental autoimmune encephalomyelitis.