[35] In a recent study, Lvovschi et al determined that cytokine levels either individually or in combination do not appear useful for differentiating severe sepsis from uncomplicated sepsis in the ED. [36] We found that, although serum levels of IL-6, IL-10 and IL-8 were significantly elevated in severe sepsis/septic shock compared to uncomplicated sepsis up to 6–8 hours post-ED arrival, significant changes in serum levels over time, especially in patients with severe sepsis, means clinical use of these markers as a routine test to predict sepsis severity or progression may be limited. This evidence concerns the gene IL6 and Sepsis.