However, in patients with severe sepsis/septic shock, there were statistically significant changes over time in serum concentrations of Resistin, IL-6, IL-10, IL-8 and MCP-1 (p = 0.024, p = 3.5×10−6, p = 5.0×10−4, p = 0.002, p = 0.049, Skillings-Mack). This evidence concerns the gene CCL2 and Shock.