In this large prospective cohort study of 92,526 participants, we found that RHR was independently associated with the risk of MI and all-cause death after controlling for potential confounders such as age, sex, body mass index, waist circumference, smoking status, drinking status, physical activity, hs-CRP, hypertension, diabetes mellitus, and dyslipidemia. Here, CRP is linked to Hypertension.