TMEM43 and neuroblastoma: Although TMEM43 was depicted by Merner et al. [2] to be a cell membrane protein, studies in mouse neuroblastoma (N2a), Baby Hamster Kidney (BHK-21) and COS-7 cells show that TMEM43 localizes predominantly to the membranes of the nuclear envelope and endoplasmic reticulum [11]–[13].