HL-1 cells have been successfully used to investigate other arrhythmogenic cardiomyopathies including those due to RyR2 mutations (ARVC2) [36]–[42], mutations of the desmosomal gene desmocollin-2 (ARVC11) [43] and si-RNA studies of the desmosomal gene plakophillin-2 (ARVC9). The gene discussed is RYR2; the disease is cardiomyopathy.