Sudden cardiac death in ARVC is believed to result from re-entrant ventricular arrhythmias due to a combination of factors including mechanical failure of intercalated (IC) discs, fibro-fatty infiltration of the myocardium and reduced connexin-43 (Cx43) gap junction conduction between cells in the myocardial syncytium. Here, GJA1 is linked to Arrhythmogenic right ventricular dysplasia.