In myeloma cells established from bone marrow of a mouse (SNU_MM1393_BM), phosphorylated form of Erk (p-ERK) was increased when treated with IL-6 only and combination of IL-6 and sIL-6R, but phosphorylated form of Akt (p-AKT) was not. This evidence concerns the gene IL6 and plasma cell myeloma.