Kheterpal et al., by reviewing 152,244 operations, identified 11 independent preoperative predictors of AKI after general surgeries: age ≥56 years, male sex, emergency surgery, intraperitoneal surgery, diabetes mellitus necessitating oral or insulin therapy, active congestive heart failure, ascites, hypertension, and mild to moderate preoperative renal insufficiency [21]. This evidence concerns the gene INS and Renal insufficiency.