In contrast, parallel studies on KSHV entry pathways in dermal endothelial cells report that c-Cbl selectively monoubiquitinates KSHV entry receptors integrin β1 and β3 molecules to facilitate KSHV macropinocytosis leading towards a successful infection whereas c-Cbl polyubiquitinates integrin β5 to direct clathrin mediated KSHV endocytosis and for directing KSHV towards lysosomal degradative pathways [31]. Here, CBL is linked to infection.