TBL1XR1 and breast cancer: Moreover, to determine whether TBLR1 promoted tumorigenicity in breast cancer cells in vivo, we established a xenograft model by inoculating nude mice (n =5/group) with MCF-7/TBLR1 or MCF-7/TBLR1-RNAi cells or their respective control vectors (MCF-7/vector or MCF-7/RNAi-vector).