By analysing iASPP expression in PCa cells with different invasive properties within locally advanced cases, we observed that nuclear (Figure 2b) and cytoplasmic (Supplementary Figure 2B) iASPP expression was significantly greater in cells at the ‘leading edge' invading the prostate capsule compared with cancer cells within intra-prostatic tumour. The gene discussed is PPP1R13L; the disease is cancer.