The finding that iASPP co-localises with TP63 within the nucleus of benign prostate epithelial cells agrees with previous findings where iASPP binds and directly regulates TP63 function.41 We observed that iASPP expression was increased in the nucleus and cytoplasm of PCa cells in a cohort of over 200 PCa samples compared with benign prostate epithelial samples. Here, TP63 is linked to posterior cortical atrophy.