p63 is known to regulate key epithelial proteins such as cadherins and cell adhesion molecules.58 Moreover, p53 is an important inhibitor of EMT59 and most PCa express wild-type p53.2, 3, 4, 5, 6 Therefore an inhibitor of p53 such as iASPP could play an important role in facilitating prostate epithelial cells to undergo EMT. The gene discussed is CDH17; the disease is posterior cortical atrophy.