p53 mutation or loss-of-heterozygosity rates in early PCa are low,2, 3, 4, 5, 6 suggesting p53 mutation is a late event in PCa and that selection for loss of p53 function occurs during PCa progression.7, 8, 9, 10, 11, 12, 13, 14, 15 Mutant p53 can induce cancer cell invasion by binding to p63 and inhibiting its transcriptional activity.16, 17, 18, 19 p63 is a member of the p53 family and shares high sequence similarity to p53 at its DNA binding domain. The gene discussed is TP63; the disease is cancer.