PPP1R13L and posterior cortical atrophy: This observation is in keeping with other published reports, suggesting that a ‘field change' phenomenon or ‘field cancerisation' effect exists during malignant transformation of prostate epithelium.62, 63, 64, 65, 66, 67, 68, 69, 70 Furthermore we observed that nuclear iASPP is enriched within PCa cells at the invasive front of locally invading tumours in vivo, and within the experimentally derived metastatic PCa cell line LNCaP-LN3 compared with parental LNCaP cells in vitro.