Regardless of this our observation that nuclear iASPP expression was increased in PCa progression was interesting given that the expression of TP63 is frequently lost in PCa.24 It is known that p63 expression defines the basal epithelial cell lineage, and we speculate that when PCa cells enter their metastatic phase there is possible cellular reprogramming, lineage change and an epithelial-to-mesenchymal transition (EMT). This evidence concerns the gene TP63 and posterior cortical atrophy.