Treatment with the proteasome inhibitor MG132 sensitised TRAIL-resistant HPV+ cervical cancer cells to TRAIL through p53-dependent upregulation of TRAIL-Rs and inactivation of XIAP.27 Overexpression of E6 was shown to protect colon cancer cells from death receptor-induced apoptosis by affecting the stability of the DISC, indicating a functional link between the presence of E6 and TRAIL signalling.28 This evidence concerns the gene TNFSF10 and malignant colon neoplasm.