Similar data were obtained in HPV+ cervical cancer cells in which XIAP downregulation increased TRAIL-induced apoptosis, in particular when combined with MG132.27 Moreover, the sensitising effect of proteasome inhibition to TRAIL in lymphoma cells with acquired TRAIL resistance could be partially reproduced by knockdown of XIAP.46 These findings suggest that XIAP partially accounts for the resistance of HPV+ cells to TRAIL as a single treatment. The gene discussed is XIAP; the disease is cervical carcinoma.