In addition, tumor diameters were measured every 3 days with an electronic digital caliper, and it could be demonstrated clearly that HepG2 cells with transfected pBabe-CXCR7 showed promotion in both size and weight in tumor growth, while LM3 cells with transfected pLKO.1-shCXCR7-1 showed suppression of tumor growth, which statistically differed from those of their vector control (P<0.05, t-test; Figures 3b and c). Here, ACKR3 is linked to neoplasm.