E2F6 and Familial prostate cancer: We have previously shown that miR-31 targets E2F6.25 E2F6 is an antiapoptotic protein that inhibits UV- and hypoxia-induced apoptosis.28,29 To determine the effects of E2F6 on chemotherapy-induced apoptosis in prostate cancer cells, we used siRNA to knockdown specifically E2F6 in PC-3 cells.