TA isoforms structurally resemble p53 and act as tumor suppressors.33 p53, TAp63 and TAp73 can transactivate many of the same target genes and execute their tumor-suppressor function by guarding the genomic stability and promoting cell cycle arrest, replicative senescence or apoptosis34, 35, 36 Around 70% of TAp73−/− mice develop tumors (mostly lung adenocarcinomas), and the rest show premature aging linked to the deregulated metabolism.37 This indicates that TAp73 is a tumor suppressor and important regulator of metabolism. This evidence concerns the gene TP53 and lung adenocarcinoma.