SIRT1 is overexpressed in different tumor types such as acute myeloid leukemia, colon and prostate cancers, but this correlation is not found for bladder carcinoma, glioblastoma nor ovarian cancer.7 The oncogenic role of SIRT1 is controversial, as this sirtuin is also involved in the maintenance of DNA integrity. The gene discussed is SIRT1; the disease is urinary bladder carcinoma.