Tv6 was described as an activator of wild-type p53 and as SIRT1 and SIRT2 inhibitor.6 We therefore investigated whether the antiproliferative effect of Tv6 in synovial sarcoma and rhabdomyosarcoma cell lines was accompanied by the stabilization and reactivation of p53 and, whether this effect was associated with sirtuin activity. This evidence concerns the gene SIRT2 and rhabdomyosarcoma.