To investigate a possible role of sirtuins on soft tissue sarcoma growth, we tested the activity of the SIRT1and SIRT2 inhibitor tenovin-6 (Tv6) in seven pediatric soft tissue sarcoma cell lines including four synovial sarcomas (wild-type p53) and three rhabdomyosarcomas (mutated p53 gene). The gene discussed is TP53; the disease is soft tissue sarcoma.